Evaluation of the Accuracy of 99DOTS, a Novel Cellphone-based Strategy for Monitoring Adherence to Tuberculosis Medications: Comparison of DigitalAdherence Data With Urine Isoniazid Testing

Clin Infect Dis. 2020 Dec 3;71(9):e513-e516. doi: 10.1093/cid/ciaa333.

Abstract

99DOTS is a cellphone-based strategy for monitoring tuberculosis medication adherence. In a sample of 597 Indian patients with tuberculosis, we compared 99DOTS' adherence assessments against results of urine isoniazid tests collected during unannounced home visits. 99DOTS had suboptimal accuracy for measuring adherence, partly due to poor patient engagement with 99DOTS.

Keywords: tuberculosis; India; digital adherence technologies; mHealth; medication adherence.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / therapeutic use
  • Cell Phone*
  • Humans
  • Isoniazid / therapeutic use
  • Medication Adherence
  • Tuberculosis* / diagnosis
  • Tuberculosis* / drug therapy

Substances

  • Antitubercular Agents
  • Isoniazid