Mechanistic Investigation of Photochemical Reactions by Mass Spectrometry

Chembiochem. 2020 Aug 17;21(16):2232-2240. doi: 10.1002/cbic.202000072. Epub 2020 Apr 21.

Abstract

This Minireview highlights the application of electrospray ionization mass spectrometry (ESI-MS) to investigating photochemical reactions. We show possible approaches to on-line ESI-MS monitoring of photocatalytic reactions and give examples of the characterization of short-lived photochemical intermediates by ion spectroscopy. The minireview also exemplifies in-depth mass spectrometric studies of photoisomerization reactions and photofragmentation reactions. Apart from mechanistic studies, the coupling of photochemistry and mass spectrometry is a powerful approach to studying structure and properties of biomolecules. We show several examples focused on investigation of intrinsic properties of model biomolecules.

Keywords: Ion spectroscopy; Mass spectrometry; Photocatalysis; Photochemistry; Reaction intermediates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Peptides / chemistry
  • Photochemical Processes*
  • Spectrometry, Mass, Electrospray Ionization*

Substances

  • Peptides