A Promising CPS1 Inhibitor Keeping Ammonia from Fueling Cancer

Ayumu Taguchi; Johannes F Fahrmann; Samir M Hanash

doi:10.1016/j.chembiol.2020.03.002

A Promising CPS1 Inhibitor Keeping Ammonia from Fueling Cancer

Cell Chem Biol. 2020 Mar 19;27(3):253-254. doi: 10.1016/j.chembiol.2020.03.002.

Authors

Ayumu Taguchi¹, Johannes F Fahrmann², Samir M Hanash²

Affiliations

¹ Division of Molecular Diagnostics, Aichi Cancer Center, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, Japan; Division of Advanced Cancer Diagnostics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan. Electronic address: a.taguchi@aichi-cc.jp.
² Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

PMID: 32200911
DOI: 10.1016/j.chembiol.2020.03.002

Abstract

Carbamoyl phosphate synthetase 1 (CPS1) drives ammonia conversion to carbamoyl phosphate, and its overexpression supports pyrimidine synthesis and tumor growth, highlighting the potential of CPS1 inhibition as a therapeutic target. In this issue of Cell Chemical Biology, Yao et al. (2020) introduce H3B-120 as a promising novel inhibitor of CPS1.

Publication types

Comment

MeSH terms

Ammonia*
Carbamoyl-Phosphate Synthase (Ammonia)
Humans
Neoplasms* / drug therapy

Substances

Ammonia
Carbamoyl-Phosphate Synthase (Ammonia)