Calculating the sample size required for developing a clinical prediction model

Affiliations

• ¹ Centre for Prognosis Research, School of Primary, Community and Social Care, Keele University, Staffordshire ST5 5BG, UK r.riley@keele.ac.uk.
• ² Centre for Prognosis Research, School of Primary, Community and Social Care, Keele University, Staffordshire ST5 5BG, UK.
• ³ Department of Biostatistics, Vanderbilt University School of Medicine, Nashville TN, USA.
• ⁴ Division of Informatics, Imaging and Data Science, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
• ⁵ Julius Center for Health Sciences, University Medical Center Utrecht, Utrecht, Netherlands.
• ⁶ Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
• ⁷ Department of Clinical Epidemiology, Leiden University Medical Center Leiden, Netherlands.