Chryso-lactams:Gold(I) derivatives of ampicillin with specific activity against Gram-positive pathogens

Bioorg Med Chem Lett. 2020 May 1;30(9):127098. doi: 10.1016/j.bmcl.2020.127098. Epub 2020 Mar 7.
No abstract available

Keywords: Antibiotic; Azide-alkyne Huisgen cycloaddition; Gold(I) complex; Gram-positive pathogen; β-Lactam.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ampicillin / analogs & derivatives*
  • Ampicillin / chemical synthesis*
  • Ampicillin / chemistry
  • Ampicillin / pharmacology
  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Gold / chemistry*
  • Gram-Positive Bacteria / drug effects*
  • Microbial Sensitivity Tests
  • Molecular Structure

Substances

  • Anti-Bacterial Agents
  • Gold
  • Ampicillin