Long-Term Effect of Half-Fluence Photodynamic Therapy on Fundus Autofluorescence in Acute Central Serous Chorioretinopathy

Martin Stattin; Stefan Hagen; Daniel Ahmed; Eva Smretschnig; Florian Frommlet; Katharina Krepler; Siamak Ansari-Shahrezaei

doi:10.1155/2020/8491712

Long-Term Effect of Half-Fluence Photodynamic Therapy on Fundus Autofluorescence in Acute Central Serous Chorioretinopathy

J Ophthalmol. 2020 Feb 17:2020:8491712. doi: 10.1155/2020/8491712. eCollection 2020.

Authors

Martin Stattin^{1

2}, Stefan Hagen^{1

2}, Daniel Ahmed^{1

2}, Eva Smretschnig^{1

2}, Florian Frommlet³, Katharina Krepler^{1

2}, Siamak Ansari-Shahrezaei^{1

2

4}

Affiliations

¹ Karl Landsteiner Institute of Retinal Research and Imaging, Vienna 1030, Juchgasse 25, Austria.
² Department of Ophthalmology, Rudolf Foundation Hospital, Vienna 1030, Juchgasse 25, Austria.
³ Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna 1090, Spitalgasse 23, Austria.
⁴ Department of Ophthalmology, Medical University of Graz, Graz 8036, Auenbruggerplatz 4, Austria.

Abstract

Purpose: To evaluate normalized short-wavelength fundus autofluorescence (SW-FAF) imaging changes over time as a predictive parameter for the retinal pigment epithelium (RPE) function in eyes compromised by acute central serous chorioretinopathy (CSCR) after indocyanine green angiography-guided verteporfin (Visudyne®, Novartis Pharma, Basel, Switzerland) photodynamic therapy (PDT) with a half-fluence rate (25 J/cm²).

Methods: Quantitative data of SW-FAF grey values (SW-FAF GV) from a 350 μm (SW-350) and 1200 μm (SW-350) and 1200 t-test was calculated to explore the differences of SW-350 and SW-1200 between one month and the long-term follow-up.

Results: Mean differences (95% CI) in SW-FAF GV between 1 month and 7 years after half-fluence PDT were 0.07 ± 0.11 for SW-350 ([95% CI: -0.002; 0.14], p=0.06) and 0.11 ± 0.15 for SW-1200 ([95% CI: 0.01; 0.21], p=0.06) and 0.11 ± 0.15 for SW-1200 ([95% CI: 0.01; 0.21], p=0.06) and 0.11 ± 0.15 for SW-1200 ([95% CI: 0.01; 0.21], p=0.06) and 0.11 ± 0.15 for SW-1200 ([95% CI: 0.01; 0.21].

Conclusion: After 7 years, normalized SW-FAF GV were significantly lower in eyes with resolved acute CSCR treated with reduced-fluence PDT compared to the follow-up after 1 month without correlation to explicit pattern changes or structural damages. Half-fluence PDT remains a safe and considerable treatment option in acute CSCR.