NLRP3 Inflammasome and Inflammatory Diseases

Zheng Wang; Simei Zhang; Ying Xiao; Wunai Zhang; Shuai Wu; Tao Qin; Yangyang Yue; Weikun Qian; Li Li

doi:10.1155/2020/4063562

NLRP3 Inflammasome and Inflammatory Diseases

Oxid Med Cell Longev. 2020 Feb 17:2020:4063562. doi: 10.1155/2020/4063562. eCollection 2020.

Authors

Zheng Wang¹, Simei Zhang¹, Ying Xiao¹, Wunai Zhang¹, Shuai Wu¹, Tao Qin¹, Yangyang Yue¹, Weikun Qian¹, Li Li²

Affiliations

¹ Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
² Department of Ophthalmology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.

Abstract

Almost all human diseases are strongly associated with inflammation, and a deep understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome composed of the NLRP3 protein, procaspase-1, and ASC plays a vital role in regulating inflammation. In this review, NLRP3 regulation and activation, its proinflammatory role in inflammatory diseases, interactions with autophagy, and targeted therapeutic approaches in inflammatory diseases will be summarized.

Publication types

Review

MeSH terms

Humans
Inflammasomes / metabolism*
Inflammation / genetics*
NLR Family, Pyrin Domain-Containing 3 Protein / metabolism*

Substances

Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein