Three-step two-pot automated production of NCA [18F]FDOPA with FlexLab module

Ya-Yao Huang; Stan Poniger; Chia-Ling Tsai; Henri J Tochon-Danguy; Uwe Ackermann; Ruoh-Fang Yen

doi:10.1016/j.apradiso.2019.108871

Three-step two-pot automated production of NCA [¹⁸F]FDOPA with FlexLab module

Appl Radiat Isot. 2020 Apr:158:108871. doi: 10.1016/j.apradiso.2019.108871. Epub 2019 Aug 22.

Authors

Ya-Yao Huang¹, Stan Poniger², Chia-Ling Tsai³, Henri J Tochon-Danguy², Uwe Ackermann⁴, Ruoh-Fang Yen⁵

Affiliations

¹ PET Center, Department of Nuclear Medicine, National Taiwan University Hospital, 7, Chung-Shan S. Road, Taipei, 100, Taiwan. Electronic address: careyyh@ntuh.gov.tw.
² Department of Molecular Imaging and Therapy, Austin Health, 145 Studley Road, Heidelberg, Victoria, 3084, Australia; iPHASE Technologies, 3 Cypress Ave, Glen Waverley, Victoria, 3150, Australia.
³ PET Center, Department of Nuclear Medicine, National Taiwan University Hospital, 7, Chung-Shan S. Road, Taipei, 100, Taiwan.
⁴ Department of Molecular Imaging and Therapy, Austin Health, 145 Studley Road, Heidelberg, Victoria, 3084, Australia.
⁵ PET Center, Department of Nuclear Medicine, National Taiwan University Hospital, 7, Chung-Shan S. Road, Taipei, 100, Taiwan; Molecular Imaging Center, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 106, Taiwan.

PMID: 32113705
DOI: 10.1016/j.apradiso.2019.108871

Abstract

Automated three-step two-pot production of no-carrier-added (NCA) [¹⁸F]FDOPA was first implemented in the iPHASE FlexLab module. Decay-corrected radiochemical yield (RCY) of [¹⁸F]FDOPA synthesized by this method was 10~14% (n = 7) with a synthesis time of ~110 min [¹⁸F]FDOPA was obtained in > 95% of radiochemical purity with a molar activity of ~431 GBq/μmol. With the method successfully implementing on the commercial FlexLab module and its built-in step-by-step activity monitoring, further processes optimization would be achieved.

Keywords: Automated production; PET imaging; [(18)F]FDOPA; iPHASE FlexLab module.