Fluorinated cryptophane-A and porphyrin-based theranostics for multimodal imaging-guided photodynamic therapy

Chem Commun (Camb). 2020 Mar 28;56(25):3617-3620. doi: 10.1039/d0cc00694g. Epub 2020 Feb 28.

Abstract

Herein, we developed fluorinated nanoemulsions with significantly enhanced in vitro and in vivo129Xe hyper-CEST MRI, 19F MRI and fluorescence imaging signals for selective and sensitive tumor detection and NIR-activated photodynamic therapy.

MeSH terms

  • Emulsions / chemical synthesis
  • Emulsions / chemistry
  • Humans
  • Magnetic Resonance Imaging
  • Multimodal Imaging*
  • Neoplasms / diagnostic imaging*
  • Neoplasms / drug therapy
  • Optical Imaging
  • Photochemotherapy*
  • Polycyclic Compounds / chemical synthesis
  • Polycyclic Compounds / chemistry*
  • Porphyrins / chemical synthesis
  • Porphyrins / chemistry*
  • Theranostic Nanomedicine*

Substances

  • Emulsions
  • Polycyclic Compounds
  • Porphyrins
  • cryptophane A