Abstract
In experiments on cats after injection of isothiobarbamine intravenously (50 mg/kg) at 30 min, intracerebral hemorrhage prevented activation of brain glucose utilization, depression of brain oxygen utilization, surplus lactate accumulation in brain, early development of brain edema and death of cats.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Animals
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Brain / drug effects*
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Brain / metabolism
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Brain Edema / etiology
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Brain Edema / metabolism
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Brain Edema / prevention & control*
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Carbohydrate Metabolism*
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Cats
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Cerebral Hemorrhage / complications*
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Cerebral Hemorrhage / metabolism
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Cerebrovascular Circulation / drug effects
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Drug Evaluation, Preclinical
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Glucose / metabolism
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Lactates / metabolism
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Lactic Acid
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Oxygen Consumption / drug effects*
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Thiobarbiturates / therapeutic use*
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Time Factors
Substances
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Lactates
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Thiobarbiturates
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Lactic Acid
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isothiobarbamin
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Glucose