[Isothiobarbamine prevention of disorders of carbohydrate and oxygen metabolism and of the development of brain edema in the early period after an intracerebral hemorrhage]

Biull Eksp Biol Med. 1988 Dec;106(12):688-90.
[Article in Russian]

Abstract

In experiments on cats after injection of isothiobarbamine intravenously (50 mg/kg) at 30 min, intracerebral hemorrhage prevented activation of brain glucose utilization, depression of brain oxygen utilization, surplus lactate accumulation in brain, early development of brain edema and death of cats.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Brain / drug effects*
  • Brain / metabolism
  • Brain Edema / etiology
  • Brain Edema / metabolism
  • Brain Edema / prevention & control*
  • Carbohydrate Metabolism*
  • Cats
  • Cerebral Hemorrhage / complications*
  • Cerebral Hemorrhage / metabolism
  • Cerebrovascular Circulation / drug effects
  • Drug Evaluation, Preclinical
  • Glucose / metabolism
  • Lactates / metabolism
  • Lactic Acid
  • Oxygen Consumption / drug effects*
  • Thiobarbiturates / therapeutic use*
  • Time Factors

Substances

  • Lactates
  • Thiobarbiturates
  • Lactic Acid
  • isothiobarbamin
  • Glucose