The Magnifying GLASS: Longitudinal Analysis of Adult Diffuse Gliomas

Ashwin Narayanan; Sevin Turcan

doi:10.1016/j.cell.2020.01.016

The Magnifying GLASS: Longitudinal Analysis of Adult Diffuse Gliomas

Cell. 2020 Feb 6;180(3):407-409. doi: 10.1016/j.cell.2020.01.016.

Authors

Ashwin Narayanan¹, Sevin Turcan²

Affiliations

¹ Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, 69120 Heidelberg, Germany.
² Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, 69120 Heidelberg, Germany. Electronic address: sevin.turcan@med.uni-heidelberg.de.

PMID: 32032515
DOI: 10.1016/j.cell.2020.01.016

Abstract

Diffuse gliomas inevitably progress, but our understanding of the molecular events associated with recurrence is limited. Recent work from the Glioma Longitudinal Analysis (GLASS) consortium (Barthel et al., 2019) reports temporal DNA sequencing on a large cohort of primary and recurrent glioma pairs, establishing the evolutionary molecular characteristics of adult diffuse gliomas.

Publication types

Comment

MeSH terms

Adult
Brain Neoplasms*
Cohort Studies
Glioma*
Humans
Neoplasm Recurrence, Local
Sequence Analysis, DNA

Grants and funding

KLI 394/FWF_/Austrian Science Fund FWF/Austria