Ruthenium(ii)-catalyzed intermolecular annulation of alkenyl sulfonamides with alkynes: access to bicyclic sultams

Lei-Lei Qian; Xiang-Ting Min; Yan-Cheng Hu; Bing-Xue Shen; Sa-Na Yang; Boshun Wan; Qing-An Chen

doi:10.1039/d0cc00093k

Ruthenium(ii)-catalyzed intermolecular annulation of alkenyl sulfonamides with alkynes: access to bicyclic sultams

Chem Commun (Camb). 2020 Feb 27;56(17):2614-2617. doi: 10.1039/d0cc00093k.

Authors

Lei-Lei Qian¹, Xiang-Ting Min¹, Yan-Cheng Hu², Bing-Xue Shen¹, Sa-Na Yang¹, Boshun Wan², Qing-An Chen²

Affiliations

¹ Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. qachen@dicp.ac.cn and University of Chinese Academy of Sciences, 100049, Beijing, China.
² Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. qachen@dicp.ac.cn.

PMID: 32016279
DOI: 10.1039/d0cc00093k

Abstract

A ruthenium-catalyzed allylic C(sp3)-H activation strategy has been employed to develop an intermolecular coupling of alkenyl sulfonamides with alkynes. This protocol features the diastereoselective construction of [3.3.0] and [4.3.0] bicyclic sultams in one step.