Multiple myeloma with clivus involvement, neurological symptoms, and 45 g/L proteinorachia

Abstract

The mechanical obstruction of cerebrospinal fluid (CSF) flow can lead to very high hyperproteinorachia. In myeloma, tumoral clivus obstruction can cause such high proteinorachia, associated with paraprotein detection in the CSF in absence of intrathecal synthesis.

Keywords: central nervous system; cerebrospinal fluid; hyperproteinorachia; multiple myeloma.