Abstract
A phytochemical study on the rhizomes of Trillium tschonoskii led to the isolation of fourteen new steroidal saponins, trillitschosides S1-S14 (1-14), along with ten known analogues (15-24). Their structures were established mainly by spectroscopic analyses as well as necessary chemical evidence. All isolated compounds were screened for the cytotoxicity against HepG2 cells, and the results demonstrated that only the known compounds 21-24 exhibited the remarkable cytotoxic activity against HepG2 cells which is much better than the positive control of 5-FU.
Keywords:
HepG2 cell; Liliaceae; Steroidal saponin; Trillitschoside; Trillium tschonoskii.
Copyright © 2020 Elsevier Inc. All rights reserved.
MeSH terms
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Cell Proliferation / drug effects
-
Cell Survival / drug effects
-
Dose-Response Relationship, Drug
-
Drug Screening Assays, Antitumor
-
Hep G2 Cells
-
Humans
-
Molecular Conformation
-
Plant Extracts / chemistry
-
Plant Extracts / isolation & purification
-
Plant Extracts / pharmacology*
-
Saponins / chemistry
-
Saponins / isolation & purification
-
Saponins / pharmacology*
-
Stereoisomerism
-
Steroids / chemistry
-
Steroids / isolation & purification
-
Steroids / pharmacology*
-
Structure-Activity Relationship
-
Trillium / chemistry*
Substances
-
Antineoplastic Agents, Phytogenic
-
Plant Extracts
-
Saponins
-
Steroids