Segregation of linked probes to myotonic dystrophy in a family demonstrating that 152 and APOC2 are on the same side of DM on 19q

K Johnson; E Nimmo; P Jones; M Weiss; M L Savontaus; M Anvret; R Bartlett; A Roses; D Shaw; P S Harper

doi:10.1007/BF00273655

Segregation of linked probes to myotonic dystrophy in a family demonstrating that 152 and APOC2 are on the same side of DM on 19q

Hum Genet. 1988 Dec;80(4):379-81. doi: 10.1007/BF00273655.

Authors

K Johnson¹, E Nimmo, P Jones, M Weiss, M L Savontaus, M Anvret, R Bartlett, A Roses, D Shaw, P S Harper, et al.

Affiliation

¹ Department of Biochemistry, St. Mary's Hospital Medical School, London, UK.

PMID: 3198115
DOI: 10.1007/BF00273655

Abstract

The two markers most closely linked to the myotonic dystrophy (DM) locus on chromosome 19 are the gene that codes for apolipoprotein CII (APOC2) and the anonymous probe D19S19 (LDR152). Both of these markers show tight linkage to DM, with maximum lod scores of greater than 20 at recombination fractions of less than 0.05. We have identified, in a family in which DM segregates, an affected individual where a meiotic recombination event has occurred in which both of these linked markers have crossed over with the gene defect. This demonstrates that APOC2 and D19S19 are probably on the same side of DM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Mapping
Chromosomes, Human, Pair 19*
Female
Genetic Linkage*
Genetic Markers*
Humans
Male
Myotonic Dystrophy / genetics*
Pedigree

Substances

Genetic Markers