Synthesis of Nontoxic Protoflavone Derivatives through Selective Continuous-Flow Hydrogenation of the Flavonoid B-Ring

Sándor B Ötvös; Máté Vágvölgyi; Gábor Girst; Ching-Ying Kuo; Hui-Chun Wang; Ferenc Fülöp; Attila Hunyadi

doi:10.1002/cplu.201800002

Synthesis of Nontoxic Protoflavone Derivatives through Selective Continuous-Flow Hydrogenation of the Flavonoid B-Ring

Chempluschem. 2018 Feb;83(2):71. doi: 10.1002/cplu.201800002. Epub 2018 Jan 15.

Authors

Sándor B Ötvös^{1

2}, Máté Vágvölgyi³, Gábor Girst^{1

3}, Ching-Ying Kuo⁴, Hui-Chun Wang⁴, Ferenc Fülöp^{1

2}, Attila Hunyadi^{3

5}

Affiliations

¹ Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 6, 6720, Szeged, Hungary.
² MTA-SZTE Stereochemistry Research Group, Hungarian Academy of Sciences, Eötvös u. 6, 6720, Szeged, Hungary.
³ Institute of Pharmacognosy, University of Szeged, Eötvös u. 6, 6720, Szeged, Hungary.
⁴ Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Shih-Chuan 1st Rd. 100, 807, Kaohsiung, Taiwan, R.O.C.
⁵ Interdisciplinary Centre of Natural Products, University of Szeged, Eötvös u. 6, 6720, Szeged, Hungary.

PMID: 31957310
DOI: 10.1002/cplu.201800002

Abstract

Invited for this month's cover is the group of Prof. Ferenc Fülöp (University of Szeged, Hungary). The cover picture shows an aerial view of the Bicaz Gorge (Transylvania) with a set of twisty hairpin turns symbolizing the challenges of selective hydrogenation of the flavonoid B-ring. The synthetic method presented can help suppress the toxic bioactivity properties of protoflavonoids thereby opening new avenues in the pharmacological investigation of these unique natural products and their synthetic analogs. Read the full text of the article at 10.1002/cplu.201700463.