Risk Factors for Early Mortality Among Patients with Glioma: A Population-Based Study

Abstract

Objective: The present study evaluated the early death and factors associated with early mortality in patients with glioma.

Methods: The data used for analysis in the present study was extracted from the Surveillance, Epidemiology, and End Results data set.

Results: A total of 58,700 patients with glioma were enrolled in the present study. The proportion of patient death within 1 month and 3 months after the diagnosis was 9.24% and 19.15% for all patients, respectively. The factors significantly associated with death within 1 month after tumor resection on multivariate analysis included age at diagnosis, year of diagnosis, tumor location, histological features, tumor size, and the absence of gross total resection, radiotherapy, and chemotherapy. We also observed similar findings in the evaluation of the factors associated with 3-month mortality.

Conclusion: The early deaths rates, including 1 and 3 months after tumor resection in patients with glioma, have decreased slightly during the previous 40 years. The risk factors for early mortality included advanced age, male sex, tumor located in the lateral ventricle, cerebellum, or brainstem, receipt of biopsy only, no chemotherapy or radiotherapy, and specific histopathological types.

Keywords: Early mortality; Glioma; Risk factors; SEER.