Jak Inhibition Prevents Bleomycin-Induced Fibrosis in Mice and Is Effective in Patients with Morphea

J Invest Dermatol. 2020 Jul;140(7):1446-1449.e4. doi: 10.1016/j.jid.2019.12.019. Epub 2020 Jan 16.

Authors

Affiliations

¹ Department of Dermatology, Yale University, New Haven, Connecticut, USA.
² Department of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
³ Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
⁴ Department of Dermatology, Yale University, New Haven, Connecticut, USA. Electronic address: brett.king@yale.edu.

PMID: 31954727
DOI: 10.1016/j.jid.2019.12.019

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Animals
Biopsy
Bleomycin / adverse effects*
Female
Fibrosis / drug therapy*
Fibrosis / prevention & control*
Humans
Immune System
Janus Kinase Inhibitors / pharmacology*
Male
Mice
Mice, Inbred C57BL
Middle Aged
Piperidines / pharmacology
Pyrimidines / pharmacology
Scleroderma, Localized / drug therapy*

Substances

Janus Kinase Inhibitors
Piperidines
Pyrimidines
Bleomycin
tofacitinib