Quality improvement in post-operative opioid and benzodiazepine regimen in adolescent patients after posterior spinal fusion

Spine Deform. 2020 Jun;8(3):441-445. doi: 10.1007/s43390-019-00002-6. Epub 2020 Jan 8.

Abstract

Study design: Prospective, quality-improvement.

Objectives: To evaluate pain management following posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS) and Scheuermann's Kyphosis (SK) determine the optimal opioid and benzodiazepine prescription amounts, and implement a multimodal post-operative pain regimen. The incidence of prescription opioid abuse is increasing in the United States. Orthopedic spine surgeons often prescribe large quantities of opioids post-operatively for pain control. Previous efforts on pain control have focused on in-patient post-operative regimens after PSF.

Methods: Between 2/1/17 and 5/30/18 patients with AIS or SK were sent home with pain diaries after discharge to document daily narcotic, benzodiazepine, non-steroidal anti-inflammatory drugs (NSAIDs), acetaminophen and gabapentin use following PSF. Diaries were collected at the 4 week post-operative visit. Data from two cohorts were reviewed: pre-intervention and post-intervention. Our prescription intervention went into effect 9/1/17.

Results: Twenty-four (30%) patients returned pain diaries. The pre-intervention cohort consisted of 12 patients (7 female; 5 males; 14.9 years (range 12-19)). Patients were prescribed on average 80 × 5 mg tabs (26-140) of oxycodone but used on average 45 tabs (12-129) over an average of 17.5 days (9-33). They were prescribed an average of 30 × 2 mg tabs (0-150) of diazepam, used on average 4.8 (0-105) tabs over 12.5 (5-25) days. The post-intervention cohort consists of 12 patients (9 female; 3 male; 14.8 years (12-19)). They were prescribed on average 50 × 5 mg tabs (35-80) of oxycodone, used 20.5 (0-39.5) tabs over 8.5 days (3-16). They were prescribed on average 18 × 2 mg tabs of diazepam (0-43), used 5.4 tabs (0-19) over 10 days (5-14).

Conclusions: This analysis has directly impacted clinical practice. Prescribed opioid and benzodiazepine doses have been decreased by over 50%, and more resources are being directed towards determining the disparity between the amount of medications prescribed and consumed in our post-operative patients.

Keywords: Adolescent spinal deformity; Benzodiazepine; Opioid; Pain management; Post-operative.

MeSH terms

  • Adolescent
  • Age Factors
  • Analgesics, Opioid / administration & dosage*
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
  • Benzodiazepines / administration & dosage*
  • Child
  • Female
  • Humans
  • Male
  • Pain Management / methods*
  • Pain, Postoperative / drug therapy*
  • Pain, Postoperative / etiology
  • Practice Patterns, Physicians' / statistics & numerical data*
  • Prescription Drug Overuse / prevention & control*
  • Prescriptions / statistics & numerical data*
  • Quality Improvement*
  • Scoliosis / surgery*
  • Spinal Fusion / adverse effects*
  • Spinal Fusion / methods
  • Substance-Related Disorders / prevention & control*
  • Time Factors
  • Young Adult

Substances

  • Analgesics, Opioid
  • Anti-Inflammatory Agents, Non-Steroidal
  • Benzodiazepines