C- to N-Center Remote Heteroaryl Migration via Electrochemical Initiation of N Radical by Organic Catalyst

Org Lett. 2020 Feb 7;22(3):795-799. doi: 10.1021/acs.orglett.9b04141. Epub 2020 Jan 10.

Abstract

Herein an exogenous oxidant- and metal-free electrochemical heteroaryl migration triggered by N radicals to construct new N-C bonds was developed. This methodology features a high atom economy and utilization rate of energy, and it is insensitive to water and air. Moreover, a user-friendly undivided cell was employed. The use of an organic catalyst makes it more efficient, green, and practical.

Publication types

  • Research Support, Non-U.S. Gov't