Devastating Gynecological Infections in Women with STAT3 Deficiency

Clin Infect Dis. 2020 Oct 23;71(7):e186-e190. doi: 10.1093/cid/ciaa020.

Abstract

We provide the first description of a series of 9 severe gynecological infections (mastitis and pelvic cellulitis) occurring in the French national cohort of women with STAT3 deficiency. Each episode had unique features in terms of clinical presentation, microbial documentation, location, treatment duration, and related persistent esthetic damage.

Keywords: STAT3 deficiency; gynecological infections; hyper IgE syndrome; mastitis; pelvic cellulitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cohort Studies
  • Female
  • Humans
  • Mastitis / genetics*
  • Mutation
  • Parametritis / genetics*
  • STAT3 Transcription Factor* / deficiency
  • STAT3 Transcription Factor* / genetics
  • Young Adult

Substances

  • STAT3 Transcription Factor
  • STAT3 protein, human