Neuromyelitis optica spectrum disorder and active tuberculosis

BMJ Case Rep. 2020 Jan 2;13(1):e231524. doi: 10.1136/bcr-2019-231524.

Abstract

Tuberculosis is on the rise again. It brings with it potential for neurological involvement both as a direct infection and as a parainfectious process. Accordingly we report the development of neurological problems affecting a 48-year-old patient's vision and sensation while being treated for active tuberculosis. At its nadir her vision deteriorated to nil perception of light and she had a sensory level to T10. Neuromyelitis optica spectrum disorder was diagnosed. We discuss our management strategy with neuromodulation in the context of active tuberculosis infection.

Keywords: TB and other respiratory infections; infection (neurology); neuroopthalmology.

Publication types

  • Case Reports

MeSH terms

  • Diagnosis, Differential
  • Female
  • Glucocorticoids / therapeutic use
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Neuromyelitis Optica / diagnostic imaging
  • Neuromyelitis Optica / etiology*
  • Neuromyelitis Optica / therapy*
  • Plasma Exchange
  • Prednisolone / therapeutic use
  • Rituximab / therapeutic use
  • Tuberculosis, Pulmonary / complications*
  • Tuberculosis, Pulmonary / diagnostic imaging
  • Tuberculosis, Pulmonary / therapy*

Substances

  • Glucocorticoids
  • Rituximab
  • Prednisolone