Pityriasis rubra pilaris-like graft-vs-host disease following allogeneic stem cell transplant in two patients

Jennifer Y Wang; Mika M Tabata; Silvina Pugliese; Darci Phillips; Jinah Kim; Wen-Kai Weng; Bernice Y Kwong

doi:10.1002/ccr3.2458

Pityriasis rubra pilaris-like graft-vs-host disease following allogeneic stem cell transplant in two patients

Clin Case Rep. 2019 Nov 14;7(12):2491-2494. doi: 10.1002/ccr3.2458. eCollection 2019 Dec.

Authors

Jennifer Y Wang¹, Mika M Tabata¹, Silvina Pugliese¹, Darci Phillips¹, Jinah Kim^{1

2

3}, Wen-Kai Weng⁴, Bernice Y Kwong¹

Affiliations

¹ Department of Dermatology Stanford University Medical Center Stanford California.
² Department of Pathology Stanford University Medical Center Stanford California.
³ Department of Dermatopathology Palo Alto Medical Foundation Palo Alto California.
⁴ Division of Blood and Marrow Transplantation Department of Medicine Stanford University Medical Center Stanford California.

Abstract

Chronic cutaneous graft-vs-host disease (GVHD) has several atypical variants. We describe two cases of GVHD with clinical and histopathologic features of pityriasis rubra pilaris (PRP), which responded to additional immunosuppression. Recognition of this newly described PRP-like clinical presentation of GVHD may prompt early consideration of additional steroid-sparing therapies.

Keywords: allogeneic hematopoietic cell transplantation; cutaneous graft‐vs‐host disease; immunosuppression; pityriasis rubra pilaris.

Publication types

Case Reports