Cholestatic liver injury induced by food additives, dietary supplements and parenteral nutrition

Vânia Vilas-Boas; Eva Gijbels; Joop Jonckheer; Elisabeth De Waele; Mathieu Vinken

doi:10.1016/j.envint.2019.105422

Cholestatic liver injury induced by food additives, dietary supplements and parenteral nutrition

Environ Int. 2020 Mar:136:105422. doi: 10.1016/j.envint.2019.105422. Epub 2019 Dec 26.

Authors

Vânia Vilas-Boas¹, Eva Gijbels¹, Joop Jonckheer², Elisabeth De Waele², Mathieu Vinken³

Affiliations

¹ Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
² Department of Intensive Care, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.
³ Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address: mathieu.vinken@vub.be.

PMID: 31884416
DOI: 10.1016/j.envint.2019.105422

Abstract

Cholestasis refers to the accumulation of toxic levels of bile acids in the liver due to defective bile secretion. This pathological situation can be triggered by drugs, but also by ingredients contained in food, food supplements and parenteral nutrition. This paper provides an overview of the current knowledge on cholestatic injury associated with such ingredients, with particular emphasis on the underlying mechanisms of toxicity.

Keywords: Cholestasis; Dietary supplements; Food additives; Herbal supplements; Parenteral nutrition.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cholestasis* / chemically induced
Dietary Supplements* / adverse effects
Food Additives* / adverse effects
Humans
Liver
Parenteral Nutrition*

Substances

Food Additives