A highly sensitive sensor based on ordered mesoporous ZnFe2O4 for electrochemical detection of dopamine

Yarong Huang; Ying Tang; Shichong Xu; Ming Feng; Yongsheng Yu; Weiwei Yang; Haibo Li

doi:10.1016/j.aca.2019.10.048

A highly sensitive sensor based on ordered mesoporous ZnFe₂O₄ for electrochemical detection of dopamine

Anal Chim Acta. 2020 Feb 1:1096:26-33. doi: 10.1016/j.aca.2019.10.048. Epub 2019 Oct 30.

Authors

Yarong Huang¹, Ying Tang², Shichong Xu³, Ming Feng³, Yongsheng Yu⁴, Weiwei Yang⁵, Haibo Li³

Affiliations

¹ Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of Education, Jilin Normal University, Changchun, 130103, China; MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, Heilongjiang, 150001, China.
² Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China.
³ Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of Education, Jilin Normal University, Changchun, 130103, China.
⁴ Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of Education, Jilin Normal University, Changchun, 130103, China; MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, Heilongjiang, 150001, China. Electronic address: yongshengyu@jlnu.edu.cn.
⁵ MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, Heilongjiang, 150001, China. Electronic address: yangww@hit.edu.cn.

PMID: 31883588
DOI: 10.1016/j.aca.2019.10.048

Abstract

Accurate and sensitive detection of dopamine (DA) is fundamental to monitor and diagnose certain neurological diseases. Herein, highly ordered mesoporous ZnFe₂O₄ (OM-ZnFe₂O₄) is prepared via a facile nanocasting method and shows the highly sensitive in the electrochemical detection of DA. The optimized OM-ZnFe₂O₄-40 shows the most excellent activity for DA oxidation in a wide linear range from 2 to 600 nM with a quick response time of 5 s, high sensitivity of 0.094 nA nM^-1 and a lower detection limit of 0.4 nM (S/N = 3). The electrode modified with OM-ZnFe₂O₄ is further successfully used to monitor the increase of DA concentration induced by K⁺-stimulation of living PC12 cells in a neurological environment. This work offers a simple and powerful strategy for designing electrodes for detecting DA in biological systems.

Keywords: Biosensor; Dopamine; Electrochemical detection; ZnFe(2)O(4).

MeSH terms

Animals
Dopamine / analysis*
Electrochemical Techniques / instrumentation*
Electrochemical Techniques / methods
Equipment Design
Ferric Compounds / chemistry*
Limit of Detection
PC12 Cells
Porosity
Rats
Zinc Compounds / chemistry*

Substances

Ferric Compounds
Zinc Compounds
ferrite
Dopamine