Phosphine-Mediated MBH-Type/Umpolung Addition Domino Sequence: Divergent Construction of Coumarins

Org Lett. 2020 Jan 17;22(2):488-492. doi: 10.1021/acs.orglett.9b04248. Epub 2019 Dec 24.

Abstract

We herein report a phosphine-mediated domino process of MBH-type reaction/umpolung γ-addition through the rational integration of the privileged reactivities of alkynoate. Simply by manipulating the nucleophilic reagent, the developed protocol offers a facile, diversity-oriented construction of a wide range of three-substituted coumarins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Coumarins / chemical synthesis*
  • Coumarins / chemistry
  • Molecular Structure
  • Phosphines / chemistry*

Substances

  • Alkynes
  • Coumarins
  • Phosphines
  • phosphine