[Population impact of rotavirus vaccination in Mexico after 10 years]

Salud Publica Mex. 2020 Jan-Feb;62(1):6-13. doi: 10.21149/9936.
[Article in Spanish]

Abstract

Objective: To evaluate the impact of rotavirus (RV) vaccination after 10 years of it´s universalization on morbidity and mortality from Acute Diarrheal Disease (ADD) in mexican children under five years of age.

Materials and methods: Annual median numbers for ADD new cases, hospitalizations and deaths were compared between pre and post universalization periods; absolute and relative reductions were calculated, considering p<0.05 values as significant.

Results: Mortality, hospitalizations and new cases from ADD in children under five decreased 52.6, 46, and 15.5% respectively, in the posuniversalization period. During rotavirus seasons, reduction in mortality, hospitalizations and new cases was 66.9, 64.7, and 28.7% respectively.

Conclusions: As of the universal introduction of RV vaccination in Mexico, significant and sustained reductions are appreciated for mortality and hospitalizations from ADD, less so for incidence. A most prominent effect is observed during the winter season.

Objetivo: Evaluar el impacto de la vacunación contra rotavirus (RV) a 10 años de su universalización sobre la morbimortalidad por enfermedad diarreica aguda (EDA) en niños mexicanos menores de cinco años.

Material y métodos: Se compararon las medianas anuales de casos nuevos, defunciones y hospitalizaciones por EDA del periodo pre y posuniversalización; se calcularon reducciones absolutas y relativas, considerando significativos valores de p<0.05.

Resultados: La mortalidad, hospitalizaciones y casos nuevos por EDA en menores de cinco años disminuyeron 52.6, 46 y 15.5% respectivamente, en el periodo posuniversalización. Durante la temporada de RV las reducciones en la mortalidad, hospitalizaciones y casos nuevos fueron de 66.9, 64.7 y 28.7%, respectivamente.

Conclusiones: A partir de la universaliza- ción de la vacuna de RV en México, se aprecian reducciones importantes y sostenidas en la mortalidad, hospitalizaciones e incidencia por EDA, con menor impacto en esta última. El mayor impacto se observa durante la temporada de RV.

Keywords: diarrhea; hospitalizations; impact; mortality; rotavirus vaccines.

MeSH terms

  • Acute Disease
  • Child, Preschool
  • Diarrhea / epidemiology*
  • Diarrhea / mortality
  • Diarrhea / prevention & control
  • Diarrhea / virology
  • Hospitalization / statistics & numerical data*
  • Hospitalization / trends
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Mexico / epidemiology
  • Rotavirus Infections / epidemiology*
  • Rotavirus Infections / mortality
  • Rotavirus Infections / prevention & control
  • Rotavirus Vaccines / administration & dosage*
  • Time Factors

Substances

  • Rotavirus Vaccines