Superior temperature sensing of small-sized upconversion nanocrystals for simultaneous bioimaging and enhanced synergetic therapy

Guofeng Liu; Fan Jiang; Yeqing Chen; Chang Yu; Binbin Ding; Shuai Shao; Mochen Jia; Ping'an Ma; Zuoling Fu; Jun Lin

doi:10.1016/j.nano.2019.102135

Superior temperature sensing of small-sized upconversion nanocrystals for simultaneous bioimaging and enhanced synergetic therapy

Nanomedicine. 2020 Feb:24:102135. doi: 10.1016/j.nano.2019.102135. Epub 2019 Dec 14.

Authors

Guofeng Liu¹, Fan Jiang², Yeqing Chen³, Chang Yu², Binbin Ding², Shuai Shao², Mochen Jia⁴, Ping'an Ma⁵, Zuoling Fu⁶, Jun Lin⁷

Affiliations

¹ State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China; Coherent Light and Atomic and Molecular Spectroscopy Laboratory, Key Laboratory of Physics and Technology for Advanced Batteries, College of Physics, Jilin University, Changchun, China.
² State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.
³ School of Applied Physics and Materials, Wuyi University, Jiangmen, Guangdong, China.
⁴ Coherent Light and Atomic and Molecular Spectroscopy Laboratory, Key Laboratory of Physics and Technology for Advanced Batteries, College of Physics, Jilin University, Changchun, China.
⁵ State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China. Electronic address: mapa675@ciac.ac.cn.
⁶ Coherent Light and Atomic and Molecular Spectroscopy Laboratory, Key Laboratory of Physics and Technology for Advanced Batteries, College of Physics, Jilin University, Changchun, China. Electronic address: zlfu@jlu.edu.cn.
⁷ State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China. Electronic address: jlin@ciac.ac.cn.

PMID: 31843660
DOI: 10.1016/j.nano.2019.102135

Abstract

The upconversion nanoparticles (UCNPs) exhibit versatility applications aiming at biological domains for decades on account of superior optical characteristics. Nevertheless, the UCNPs are confronted with tremendous difficulties in biological field owing to large grain size, low fluorescence efficiency, and single function. Herein, the small-sized CaF₂: Yb³⁺/Er³⁺ UCNPs coated with NaGdF₄ shells (activator and inert, UCNPs-RBHA-Pt-PEG) not only burst out strong fluorescence, but also provide prominent diagnosability by taking advantage of magnetic resonance (MR) imaging as well as temperature sensing and inhibiting capability for CT26 tumor tissues based on synergetic therapy modality of photodynamic therapy (PDT) and chemotherapy. Ultimately, the tumor sizes decrease visibly after injected with UCNPs-RBHA-Pt-PEG and simultaneously irradiated with near infrared (NIR) light at low power density (0.35 W/cm², 6 min). In summary, the small-sized and strong-fluorescent single nanoparticles with multi-functions may provide a valuable enlightenment for diagnosis and treatment of cancer in the future.

Keywords: Calcium fluoride; Synergetic therapy; Temperature sensing; Upconversion luminescence.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Calcium Fluoride / chemistry
Cell Line, Tumor
Mice
Models, Theoretical
Nanoparticles / chemistry*
Reactive Oxygen Species / metabolism
Temperature
Ultraviolet Rays

Substances

Reactive Oxygen Species
Calcium Fluoride