Isolated orbital amyloidosis causing internal and external ophthalmoplegia

Mary-Magdalene Ugo Dodd; Natalie Wolkow; Mary Elizabeth Cunnane; Lina Ma; Thaddeus P Dryja; David Hunter

doi:10.1016/j.jaapos.2019.11.003

Isolated orbital amyloidosis causing internal and external ophthalmoplegia

J AAPOS. 2020 Feb;24(1):48-51.e1. doi: 10.1016/j.jaapos.2019.11.003. Epub 2019 Dec 9.

Authors

Mary-Magdalene Ugo Dodd¹, Natalie Wolkow², Mary Elizabeth Cunnane³, Lina Ma⁴, Thaddeus P Dryja⁴, David Hunter⁵

Affiliations

¹ Section of Ophthalmology, Department of Surgery, Cummings School of Medicine, University of Calgary, Calgary, Alberta. Electronic address: ugo.dodd@ahs.ca.
² Division of Ophthalmic Plastic Surgery, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts; David G. Cogan Laboratory of Ophthalmic Pathology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
³ Department of Radiology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
⁴ David G. Cogan Laboratory of Ophthalmic Pathology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
⁵ Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

PMID: 31830573
DOI: 10.1016/j.jaapos.2019.11.003

Abstract

Amyloid is a protein precursor known to deposit in ocular tissue. Although its presentation is protean, it is rarely seen in the orbit. We report the case of an 85-year-old woman with primary orbital amyloidosis causing internal and external ophthalmoplegia. Strabismus surgery with muscle biopsy alleviated her symptoms and assisted with solving the diagnostic challenge.

Publication types

Case Reports

MeSH terms

Aged, 80 and over
Amyloidosis / complications*
Amyloidosis / diagnosis
Biopsy
Female
Humans
Magnetic Resonance Imaging
Oculomotor Muscles / diagnostic imaging*
Ophthalmoplegia / diagnosis
Ophthalmoplegia / etiology*
Orbit / diagnostic imaging*
Tomography, X-Ray Computed