Abstract
By assembling DNAzyme on DNA nanowires through DNA hybridization, we have developed a novel accelerated DNAzyme-based fluorescent nanoprobe for fast, sensitive and selective detection of miRNA. Moreover, the strategy was successfully applied for in situ imaging of miRNA-21 in different cell lines.
MeSH terms
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Cell Line, Tumor
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DNA, Catalytic / chemistry*
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Fluorescent Dyes / chemistry*
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Humans
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Limit of Detection
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MicroRNAs / analysis*
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MicroRNAs / metabolism
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Microscopy, Confocal*
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Nanowires / chemistry*
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Nucleic Acid Hybridization
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Spectrometry, Fluorescence
Substances
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DNA, Catalytic
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Fluorescent Dyes
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MicroRNAs