Effect of Benzo[a]pyrene-DNA Adduct in Cord Blood on the Neurodevelopment of 12-Month-Old Infants in Qingdao City

Yong Zhang; Yuehua Yang; Qian Zhang; Jing Cui; Abdul Rahaman; Xiao-Rong Huang; Ya Su; Ruqin Gao; Bingling Wang; Zulqarnain Baloch

doi:10.2147/NDT.S219244

Effect of Benzo[a]pyrene-DNA Adduct in Cord Blood on the Neurodevelopment of 12-Month-Old Infants in Qingdao City

Neuropsychiatr Dis Treat. 2019 Dec 2:15:3351-3357. doi: 10.2147/NDT.S219244. eCollection 2019.

Authors

Yong Zhang^#¹, Yuehua Yang^#², Qian Zhang^#³, Jing Cui⁴, Abdul Rahaman⁵, Xiao-Rong Huang^{6

7}, Ya Su⁴, Ruqin Gao⁴, Bingling Wang⁴, Zulqarnain Baloch⁶

Affiliations

¹ Department of Paediatric Surgery, Qingdao Women and Children's Hospital, Qingdao, People's Republic of China.
² Department of Obstetrics, The Affiliated Central Hospital of Qingdao University, Qingdao, People's Republic of China.
³ Department of Child Health Care, Huangdao Maternity and Child Health Care Hospital of Qingdao, Qingdao, People's Republic of China.
⁴ Department of Environmental Health, Qingdao Centers for Disease Control and Prevention/Qingdao Institute for Preventive Medicine, Qingdao, People's Republic of China.
⁵ School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, People's Republic of China.
⁶ Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, People's Republic of China.
⁷ College of Veterinary Medicine, South China Agricultural University, Guangzhou, 51062, People's Republic of China.

^# Contributed equally.

Abstract

Introduction: The study was designed to explore the possible adverse effects of prenatal polycyclic aromatic hydrocarbons (PAHs) on the neurodevelopment of the infants at the age of 12 months in a birth cohort in Qingdao of China. Benzo[a]pyrene (BaP)-DNA adduct level in umbilical cord blood was measured by enzyme immunoassay.

Methods: Child neurodevelopment was assessed at both 6 months and 12 months of age using the Gesell Development Inventory (GDI).

Results: This study results reveal that multivariate linear analysis, cord BaP-DNA adduct level was inversely associated with developmental quotient score in the adaptive domain [β = -0.08; 95% CI: (-0.16, -0.003); p = 0.04], gross motor domain [β = -0.10; 95% CI: (-0.20, -0.01); p = 0.02], fine motor domain [β = -0.15; 95% CI: (-0.25, -0.05); p = 0.01], language domain [β = -0.12; 95% CI: (-0.21, -0.03); p = 0.02], and personal-social domain [β = -0.13; 95% CI: (-0.22, -0.04); p<0.01]. Further, multivariate logistic regression analysis showed increased cord BaP-DNA adduct levels associated with increased odds of delayed in language domain.

Conclusion: In conclusion, the study suggested that prenatal PAH exposure monitored by umbilical cord blood BaP-DNA adducts may adversely affect the neurodevelopment of the infants at 12 months of age.

Keywords: China; PAH-DNA adducts; infant; neurodevelopment; polycyclic aromatic hydrocarbons.

Grants and funding

This study was partly supported by grants from the National Natural Science Foundation of China (No: 81372955), Qingdao Outstanding Health Professional Development Fund, Qingdao Key Health Discipline Development Fund, the Projects Of Medical and Health Technology Development Program in Shandong province (No: 2016WS0309), Central Government Fund (snhj01), and China WCH of the China CDC BiosTime Maternal and Infant Nutrition and Health Research Fund (2017FYH008).