Short Communication: Comparison of Calculated Low-Density Lipoprotein Cholesterol (LDL-C) Values in HIV-Infected and HIV-Uninfected Men Using the Traditional Friedewald and the Novel Martin-Hopkins LDL-C Equations

Edward E Schneider; Sudipa Sarkar; Joseph B Margolick; Seth S Martin; Wendy S Post; Todd T Brown

doi:10.1089/AID.2019.0220

Short Communication: Comparison of Calculated Low-Density Lipoprotein Cholesterol (LDL-C) Values in HIV-Infected and HIV-Uninfected Men Using the Traditional Friedewald and the Novel Martin-Hopkins LDL-C Equations

AIDS Res Hum Retroviruses. 2020 Mar;36(3):176-179. doi: 10.1089/AID.2019.0220. Epub 2020 Jan 6.

Authors

Edward E Schneider¹, Sudipa Sarkar², Joseph B Margolick¹, Seth S Martin³, Wendy S Post³, Todd T Brown²

Affiliations

¹ Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
² Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins School of Medicine, Baltimore, Maryland.
³ Division of Cardiology, Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins School of Medicine, Baltimore, Maryland.

Abstract

The Martin-Hopkins equation used to calculate low-density lipoprotein cholesterol (LDL-C) is more accurate than the traditional Friedewald equation, especially at higher triglyceride levels, which are more common in people with HIV (PWH). Thus, using LDL-C values calculated by the Martin-Hopkins equation may improve clinical care of PWH.

Keywords: HIV; LDL-C; Martin–Hopkins LDL-C equation; hypertriglyceridemia; low-density lipoprotein cholesterol.

Publication types

Comparative Study
Multicenter Study
Research Support, N.I.H., Extramural

MeSH terms

Aged
Cholesterol, LDL / blood*
HIV Infections / blood*
HIV Infections / complications
Humans
Hypertriglyceridemia / blood
Hypertriglyceridemia / etiology
Male
Middle Aged
Risk Assessment

Substances

Cholesterol, LDL

Abstract

Publication types

MeSH terms

Substances

Grants and funding