Characterization of a cryptic PML-RARA fusion by mate-pair sequencing in a case of acute promyelocytic leukemia with a normal karyotype and negative RARA FISH studies

Leuk Lymphoma. 2020 Apr;61(4):975-978. doi: 10.1080/10428194.2019.1699081. Epub 2019 Dec 6.

Authors

Affiliations

¹ Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
² Department of Pathology, Gunderson Lutheran Medical Center, La Crosse, WI, USA.
³ Center for Individualized Medicine-Biomarker Discovery, Mayo Clinic, Rochester, MN, USA.
⁴ Division of Hematopathology, Department of Laboratory Medicine and Genomics, Mayo Clinic, Rochester, MN, USA.

PMID: 31809670
DOI: 10.1080/10428194.2019.1699081

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 17
Humans
Karyotype
Leukemia, Promyelocytic, Acute* / diagnosis
Leukemia, Promyelocytic, Acute* / genetics
Oncogene Proteins, Fusion / genetics
Promyelocytic Leukemia Protein
Retinoic Acid Receptor alpha / genetics
Translocation, Genetic

Substances

Oncogene Proteins, Fusion
Promyelocytic Leukemia Protein
Retinoic Acid Receptor alpha