Lysosomal size matters

Abstract

Lysosomes are key cellular catabolic centers that also perform fundamental metabolic, signaling and quality control functions. Lysosomes are not static and they respond dynamically to intra- and extracellular stimuli triggering changes in organelle numbers, size and position. Such physical changes have a strong impact on lysosomal activity ultimately influencing cellular homeostasis. In this review, we summarize the current knowledge on lysosomal size regulation, on its physiological role(s) and association to several disease conditions.

Keywords: AMPK; BORC; LAMTOR; PIKfyve; PtdIns(3)P; PtdIns(3,5)P2; PtdIns(4,5)P2; V-ATPase; autolysosome; autophagy; endolysosome; fission; fusion; late endosome; lysosomal acidification; lysosomal reformation; lysosomal storage disorders; lysosome.