Amplification and overexpression of E2 ubiquitin conjugase UBE2T promotes homologous recombination in multiple myeloma

Blood Adv. 2019 Dec 10;3(23):3968-3972. doi: 10.1182/bloodadvances.2019000181.

Abstract

  1. UBE2T is frequently amplified and/or overexpressed and is required for homologous recombination activity in multiple myeloma cells.

  2. UBE2T is a potential therapeutic target to increase chemosensitivity in multiple myeloma cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Homologous Recombination / genetics*
  • Humans
  • Multiple Myeloma / genetics*
  • Multiple Myeloma / pathology
  • Ubiquitin / metabolism*
  • Ubiquitin-Conjugating Enzymes / metabolism*

Substances

  • Ubiquitin
  • UBE2T protein, human
  • Ubiquitin-Conjugating Enzymes