Evaluation of posaconazole antifungal prophylaxis in reducing the incidence of invasive aspergillosis in patients with acute myeloid leukemia

Curr Res Transl Med. 2020 Jan;68(1):23-28. doi: 10.1016/j.retram.2019.11.002. Epub 2019 Nov 28.

Abstract

Purpose of the study: Invasive aspergillosis (IA) is the most prevalent invasive fungal disease (IFD) in neutropenic patients. Environment is the main source of Aspergillus spores aerosolization especially during building construction. International guidelines recommend mechanical protection during hospital building works; otherwise the use of antifungal prophylaxis is not clearly indicated. Our objective was to determine the efficacy of antifungal prophylaxis by posaconazole on IA incidence in acute myeloid leukemia population and to analyse the benefit of this prophylaxis and HEPA-filters during hospital buildings works.

Patients and methods: We included patients treated for acute myeloid leukemia at Brest teaching hospital from January 2009 to December 2015. We compared incidence of IA in the group treated by posaconazole from 2012 to 2015 to the incidence of IA in the first group who did not receive antifungal prophylaxis (from 2009 to 2011). The one-year overall survival was also analyzed using the Kaplan-Meier method.

Results: 245 patients were enrolled including 151 treated with posaconazole. 23 IA were diagnosed between 2009 and 2011 (without antifungal prophylaxis), then 31 between 2012 and 2015 (with posaconazole) without statistical difference between the incidence densities (0.34 per 100 hospitalization-days vs. 0.30 per 100 hospitalization-days, p = 0.71). Incidence density of IA increased during building works (2.40 per 100 hospitalization-days vs. 0.28 per 100 hospitalization-days, p < 0.0001). The incidence density of IA significantly decreased during construction periods when posaconazole prophylaxis was used (1.59 per 100 hospitalization-days vs. 4.87 per 100 hospitalization-days p < 0.0001).

Conclusion: Our study suggests, for the first time, the interest of antifungal prophylaxis in addition to HEPA filtration in prevention of IA during hospital building works.

Keywords: Acute myeloid leukemia; Antifungal prophylaxis; Construction works; Invasive aspergillosis.

MeSH terms

  • Adult
  • Aerosols
  • Air Filters
  • Air Microbiology
  • Air Pollution, Indoor
  • Antifungal Agents / therapeutic use*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Aspergillosis / epidemiology
  • Aspergillosis / prevention & control*
  • Aspergillus / drug effects
  • Aspergillus / isolation & purification
  • Aspergillus / physiology
  • Combined Modality Therapy
  • Environmental Exposure
  • Febrile Neutropenia / complications
  • Female
  • Filtration
  • France
  • Hematopoietic Stem Cell Transplantation
  • Hospital Design and Construction
  • Hospitals, Teaching
  • Humans
  • Incidence
  • Invasive Fungal Infections / epidemiology
  • Invasive Fungal Infections / prevention & control*
  • Kaplan-Meier Estimate
  • Leukemia, Myeloid, Acute / complications*
  • Leukemia, Myeloid, Acute / mortality
  • Leukemia, Myeloid, Acute / therapy
  • Male
  • Middle Aged
  • Prospective Studies
  • Retrospective Studies
  • Spores, Fungal
  • Triazoles / therapeutic use*

Substances

  • Aerosols
  • Antifungal Agents
  • Triazoles
  • posaconazole