Black Bone Disease of the Skull

David E Smolar; Monica C Mureb; Robert A Fenstermaker

doi:10.1016/j.wneu.2019.11.114

Black Bone Disease of the Skull

World Neurosurg. 2020 Feb:134:548. doi: 10.1016/j.wneu.2019.11.114. Epub 2019 Nov 27.

Authors

David E Smolar¹, Monica C Mureb², Robert A Fenstermaker³

Affiliations

¹ Roswell Park Comprehensive Cancer Center, State University of New York, Buffalo, New York, USA; Jacobs School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York, USA.
² New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, USA.
³ Roswell Park Comprehensive Cancer Center, State University of New York, Buffalo, New York, USA. Electronic address: dzbuffns@aol.com.

PMID: 31785440
DOI: 10.1016/j.wneu.2019.11.114

Abstract

We present an image of a patient's skull characterized by dark, irregular discoloration. This was discovered incidentally in a 66-year-old man who underwent craniotomy for resection of a glioblastoma. This image demonstrates cranial black bone disease. This is an abnormal bone pigmentation associated with long-term tetracycline use, as occurred in this patient.

Keywords: Black bone; Craniotomy; Glioblastoma; Skull; Tetracycline.

Publication types

Case Reports

MeSH terms

Aged
Anti-Bacterial Agents / pharmacology
Bone Diseases / drug therapy*
Bone Diseases / surgery
Craniotomy / methods
Glioblastoma / drug therapy*
Humans
Male
Skull / drug effects*
Skull / surgery
Tetracycline / pharmacology*
Time
Tomography, X-Ray Computed

Substances

Anti-Bacterial Agents
Tetracycline