Pulsed-field gel mapping studies in the vicinity of the fragile site at Xq27.3

Am J Med Genet. 1988 May-Jun;30(1-2):581-91. doi: 10.1002/ajmg.1320300159.

Abstract

Physical mapping strategies are being employed for an analysis of the fragile X site region. Deletion breakpoints which may be close to the fragile site appear to be at a distance of at least several hundred kb from the nearest DNA probes. Further evidence is found for physical linkage between St14 (DXS52), DX13 (DXS15) and MN12 (DXS33). The data indicate differences in CG content and/or methylation levels between the distal and proximal sides of the fragile site.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Deletion
  • Chromosome Fragile Sites
  • Chromosome Fragility*
  • Chromosome Mapping*
  • DNA Probes
  • Electrophoresis
  • Female
  • Fragile X Syndrome / genetics*
  • Genetic Linkage
  • Humans
  • Male
  • Sex Chromosome Aberrations / genetics*
  • X Chromosome*

Substances

  • DNA Probes