Self-assembly and self-delivery nanodrug of bortezomib: a simple approach to achieve the trade-off between functionality and druggability

Fuli Zhao; Xiang Liu; Anjie Dong; Liandong Deng; Weiwei Wang; Jianhua Zhang

doi:10.1039/c9tb02174d

Self-assembly and self-delivery nanodrug of bortezomib: a simple approach to achieve the trade-off between functionality and druggability

J Mater Chem B. 2019 Dec 21;7(47):7490-7493. doi: 10.1039/c9tb02174d. Epub 2019 Nov 25.

Authors

Fuli Zhao¹, Xiang Liu², Anjie Dong³, Liandong Deng⁴, Weiwei Wang⁵, Jianhua Zhang⁶

Affiliations

¹ Department of Polymer Science and Engineering, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. jhuazhang@tju.edu.cn and CNOOC Tianjin Chemical Research and Design Institute Co., Ltd, Tianjin 300131, China.
² Department of Polymer Science and Engineering, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. jhuazhang@tju.edu.cn and Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China. wwwangtj@163.com.
³ Department of Polymer Science and Engineering, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. jhuazhang@tju.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China.
⁴ Department of Polymer Science and Engineering, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. jhuazhang@tju.edu.cn.
⁵ Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China. wwwangtj@163.com.
⁶ Department of Polymer Science and Engineering, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. jhuazhang@tju.edu.cn and Tianjin Key Laboratory of Membrane Science and Desalination Technology, Tianjin University, Tianjin 300350, China.

PMID: 31763663
DOI: 10.1039/c9tb02174d

Abstract

Bortezomib, dietary tannic acid and an FDA-approved excipient poloxamer were used as building blocks without any chemical syntheses and modifications to construct a dynamic self-delivery nanodrug with high drug loading, outstanding stability, tunable size and pH-controlled release. This strategy with high druggability, reproducibility and productivity might be desirable and useful for pharmaceutical formulations of bortezomib.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials / chemistry
Biocompatible Materials / pharmacology
Bortezomib / chemistry*
Bortezomib / metabolism
Cell Survival / drug effects
Drug Carriers / chemistry*
Drug Liberation
Humans
Hydrogen-Ion Concentration
MCF-7 Cells
Nanoparticles / chemistry*
Particle Size
Poloxamer / chemistry
Poloxamer / pharmacology
Proteasome Inhibitors / chemistry
Proteasome Inhibitors / metabolism
Tannins / chemistry
Tannins / pharmacology

Substances

Biocompatible Materials
Drug Carriers
Proteasome Inhibitors
Tannins
Poloxamer
Bortezomib