Negative symptom configuration in first episode Schizophrenia: findings from the "Parma Early Psychosis" program

Nord J Psychiatry. 2020 May;74(4):251-258. doi: 10.1080/08039488.2019.1695286. Epub 2019 Nov 25.

Abstract

Purpose: Identifying distinct dimensions of negative symptoms in First Episode Schizophrenia (FES) might result in a better understanding and treatment of this invalidating symptomatology. Aim of this study was to examine negative symptom structure in FES patients using the Positive and Negative Syndrome Scale (PANSS).Materials and Methods: All 147 participants, aged 12-35 years, completed the PANSS and the Global Assessment of Functioning (GAF) scale. A principal component analysis with varimax rotation was performed to investigate PANSS negative symptom structure in the FES total sample.Results: A 2-factor model (i.e. "Expressive Deficits" and "Asociality" dimensions) was identified. Only "Expressive Deficits" domain had a significant negative correlation with baseline GAF score.Conclusions: This bipartite solution seems to be adequate to describe the phenomenological variety of negative symptoms experienced by FES individuals at the point of entry in early intervention services.

Keywords: Negative symptoms; dimensions; early psychosis; factor analysis; first episode schizophrenia.

Publication types

  • Pragmatic Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Early Diagnosis
  • Female
  • Humans
  • Italy / epidemiology
  • Male
  • Principal Component Analysis / methods
  • Psychiatric Status Rating Scales*
  • Psychotic Disorders / diagnosis
  • Psychotic Disorders / epidemiology
  • Psychotic Disorders / psychology
  • Schizophrenia / diagnosis*
  • Schizophrenia / epidemiology*
  • Schizophrenic Psychology*
  • Young Adult