Do All Roads Lead to Rome in G-Protein Activation?

Pradipta Ghosh; Mikel Garcia-Marcos

doi:10.1016/j.tibs.2019.10.010

Do All Roads Lead to Rome in G-Protein Activation?

Trends Biochem Sci. 2020 Mar;45(3):182-184. doi: 10.1016/j.tibs.2019.10.010. Epub 2019 Nov 18.

Authors

Pradipta Ghosh¹, Mikel Garcia-Marcos²

Affiliations

¹ Department of Medicine and Cellular and Molecular Medicine, University of California, San Diego, CA 92093, USA. Electronic address: prghosh@ucsd.edu.
² Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA. Electronic address: mgm1@bu.edu.

Abstract

High-resolution structural studies on G-protein-coupled receptors (GPCRs) have flourished recently, providing long-sought insights into the dynamic process of guanine nucleotide-binding protein (G-protein) activation. In parallel, analogous studies are starting to shed light on how the same G-proteins are activated by non-GPCR proteins. Can we learn about common themes and variations in G-protein activation from them?

Keywords: GEF; GPCR; GTPase; allosterism.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

GTP-Binding Proteins / chemistry
GTP-Binding Proteins / metabolism*
Humans
Protein Conformation
Receptors, G-Protein-Coupled / metabolism

Substances

Receptors, G-Protein-Coupled
GTP-Binding Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding