Antibiotic Duration, but Not Abscess Size, Impacts Clinical Cure of Limited Skin and Soft Tissue Infection After Incision and Drainage

Jason G Lake; Loren G Miller; Stephanie A Fritz

doi:10.1093/cid/ciz1129

Antibiotic Duration, but Not Abscess Size, Impacts Clinical Cure of Limited Skin and Soft Tissue Infection After Incision and Drainage

Clin Infect Dis. 2020 Jul 27;71(3):661-663. doi: 10.1093/cid/ciz1129.

Authors

Jason G Lake¹, Loren G Miller², Stephanie A Fritz¹

Affiliations

¹ Department of Pediatrics, School of Medicine, Washington University in St Louis, St Louis, Missouri, USA.
² Department of Medicine, Harbor-UCLA Medical Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA.

Abstract

Antibiotics are frequently prescribed following incision and drainage of cutaneous abscesses. In subgroup analyses from a recent clinical trial, we observed higher likelihood of cure with antibiotic courses beyond 5 or 7 days (up to 10). Among this cohort, for abscesses ≤5 cm, size did not modify the antibiotic effect.

Keywords: SSTI; adjunctive antibiotic; clindamycin; incision and drainage; trimethoprim-sulfamethoxazole.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Abscess / drug therapy
Abscess / surgery
Anti-Bacterial Agents / therapeutic use
Drainage
Humans
Soft Tissue Infections* / drug therapy
Staphylococcal Skin Infections* / drug therapy

Substances

Anti-Bacterial Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding