Purpose: To aid nurses in dosing sufentanil sublingual tablet (SST) 30 mcg administered via a single-dose applicator, dosing requirements and efficacy of SST 30 mcg were analyzed across age, sex, race, and body mass index subgroups.
Design: Patient characteristics were pooled from three postoperative studies (two placebo-controlled and one open-label) and one open-label emergency department study. Drug dosing and efficacy data were pooled from the postoperative studies.
Methods: Efficacy was assessed through summed pain intensity difference to baseline during 12 hours across subgroups.
Findings: Mean (standard deviation) drug doses administered from 0 to 12 hours was 3.9 (2.0) for SST 30 mcg and was less frequent for older (≥65 years) versus younger patients. The summed pain intensity difference to baseline during 12 hours was superior with SST 30 mcg versus placebo across all subgroups.
Conclusions: SST 30 mcg is a sublingual opioid analgesic with efficacy across demographic subgroups.
Keywords: acute pain; analgesia; opioid; sublingual.
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.