Life-threatening Hypercalcemia as the First Manifestation of Acute Lymphoblastic Leukemia

Indian Pediatr. 2019 Nov 15;56(11):972-974.

Abstract

Hypercalcemia of malignancy, usually reported in adults in advanced stages, is rare in children. A 4-year-old boy presented with intermittent episodes of severe hypercalcemia, which improved with intravenous hydration therapy, furosemide and bisphosphonates as the initial manifestation of occult acute lymphoblastic leukemia. Pediatricians should rule out hematological malignancy in patients with severe hypercalcemia.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Bone Marrow Examination / methods
  • Bone and Bones / diagnostic imaging
  • Chelating Agents / administration & dosage
  • Child, Preschool
  • Diagnosis, Differential
  • Diphosphonates / administration & dosage*
  • Diuretics / administration & dosage
  • Fluid Therapy / methods*
  • Furosemide / administration & dosage*
  • Humans
  • Hypercalcemia* / diagnosis
  • Hypercalcemia* / etiology
  • Hypercalcemia* / therapy
  • Male
  • Positron-Emission Tomography / methods
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / blood
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / complications
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / diagnosis
  • Severity of Illness Index

Substances

  • Chelating Agents
  • Diphosphonates
  • Diuretics
  • Furosemide