A nanowire-integrated thermoresponsive microfluidic platform for on-demand enrichment and colorimetric detection of pathogenic bacteria

J Mater Chem B. 2019 Dec 14;7(46):7301-7305. doi: 10.1039/c9tb01923e. Epub 2019 Nov 13.

Abstract

A nanowire-integrated thermoresponsive microfluidic platform is developed for bacterial enrichment and on-demand release. This microfluidic platform can enable selective and highly sensitive S. aureus detection in blood samples down to trace concentrations (40 CFU mL-1) by the naked eye with the help of a click reaction-assisted colorimetric assay.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylic Resins / chemistry
  • Biosensing Techniques
  • Click Chemistry
  • Colorimetry / instrumentation
  • Colorimetry / methods*
  • Copper
  • Equipment Design
  • Escherichia coli / isolation & purification
  • Limit of Detection
  • Microfluidic Analytical Techniques*
  • Microfluidics*
  • Microscopy, Electron, Scanning
  • Nanowires / chemistry*
  • Polymerase Chain Reaction
  • Spectroscopy, Fourier Transform Infrared
  • Staphylococcus aureus / isolation & purification*

Substances

  • Acrylic Resins
  • poly-N-isopropylacrylamide
  • Copper