Diverse and Flexible Transmission of fosA3 Associated with Heterogeneous Multidrug Resistance Regions in Salmonella enterica Serovar Typhimurium and Indiana Isolates

Antimicrob Agents Chemother. 2020 Jan 27;64(2):e02001-19. doi: 10.1128/AAC.02001-19. Print 2020 Jan 27.

Abstract

We identified fosA3 at a rate of 2.6% in 310 Salmonella isolates from food animals in Guangdong province, China. The fosA3 gene was genetically linked to diverse antibiotic resistance genes (ARGs), including mcr-1, blaCTX-M-14/55, oqxAB, and rmtB These gene combinations were embedded in heterogeneous fosA3-containing multidrug resistance regions on the transferable ST3-IncHI2 and F33:A-:B- plasmids and the chromosome. This indicated a great flexibility of fosA3 cotransmission with multiple important ARGs among Salmonella species.

Keywords: IncHI2 plasmids; Salmonella; chromosomally encoded; multidrug resistance; plasmid-mediated fosfomycin resistance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Fosfomycin / pharmacology*
  • Plasmids / genetics
  • Salmonella Infections / epidemiology
  • Salmonella Infections / microbiology*
  • Salmonella typhimurium / drug effects
  • Salmonella typhimurium / genetics*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Fosfomycin