Abstract
PTEN is a phosphatase that functions as a tumour suppressor by antagonizing the PI3K–AKT pathway. However, a study now demonstrates that translational variants of PTEN enable new interactions between PTEN and the COMPASS complex, identifying a new role for PTEN in modifying gene expression via COMPASS-mediated histone H3 lysine 4 methylation.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Carcinogenesis*
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Histone-Lysine N-Methyltransferase
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Humans
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Intracellular Signaling Peptides and Proteins
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PTEN Phosphohydrolase*
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Protein Isoforms
Substances
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Intracellular Signaling Peptides and Proteins
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Protein Isoforms
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WDR5 protein, human
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Histone-Lysine N-Methyltransferase
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PTEN Phosphohydrolase
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PTEN protein, human