Objective: To analyze the related factors of esophageal squamous cell carcinoma and precancerous lesions among residents aged 40-69 years old in rural areas of Shandong Province. Methods: In October 2018, 300 villages in 13 counties of the Shandong upper gastrointestinal cancerearly diagnosis and treatment projectin 2017 were selected as research areas, and 30 400 residents aged 40-69 were recruited in this study. The demographic characteristics, health status and lifestyle information were collected through the questionnaire survey, and endoscope iodine staining and indicative biopsy methods were used for cancer screening among eligible people.The multivariate logistic regression model was used to analyze the risk factors for esophageal cancer and precancerous lesions. Results: The subjects in this study were (56.42±7.24) years old, including 13 193 males (43.40%).There were 936 cases of esophageal cancer and precancerous lesions (3.08%), including 521 males and 415 females.Compared with women, 40-49 years old, high level education, drinking tap water, regular intake of meat, eggs and milk, and family average annual income more than 30 000 RMB, men (OR=1.90, 95%CI: 1.65-2.19), 60-69 years old (OR=5.28, 95%CI: 4.11-7.30), primary school education or below (OR=1.50, 95%CI: 1.20-1.89), drinking groundwater (OR=1.71, 95%CI: 1.38-2.13), never eating meat, eggs and milk (OR=1.48, 95%CI: 1.22-1.80), and family average annual income less than 30 000 RMB (OR=1.41, 95%CI: 1.16-1.70) would increase the risk of esophageal cancer and precancerous lesions. Conclusion: The gender, age, educational level, annual household income, drinking water source, the frequency of eating meat, egg and milk were related to the occurrence of esophageal cancer and precancerous lesions among 40-69 years old residents in rural areas of Shandong Province.
目的： 分析山东省农村地区40~69岁居民食管鳞癌及癌前病变的相关因素。 方法： 于2018年10月，以2017年山东省上消化道癌早诊早治项目的13个县300个行政村为研究地区，招募40~69岁30 400名居民。通过问卷调查收集人口学特征、健康状况和生活方式等信息，利用"内镜下染色+病理活检"技术对研究对象进行筛查并确诊，并采用多因素logistic回归模型分析食管鳞癌及癌前病变的相关因素。 结果： 研究对象年龄为（56.42±7.24）岁，其中男性13 193名（43.40%）。食管鳞癌及癌前病变936例（3.08%），男、女性分别为521、415例。多因素logistic回归模型分析结果显示，与女性、40~49岁、文化程度为高中及以上、饮用自来水、经常摄入肉蛋奶类、家庭人均年收入≥30 000元者相比，男性、60~69岁、文化程度为小学及以下、饮用地下水、从不摄入肉蛋奶类、家庭人均年收入<30 000元者发生食管鳞癌及癌前病变的患病风险较高，OR(95%CI）值分别为1.90（1.65~2.19）、5.28（4.11~7.30）、1.50（1.20~1.89）、1.71（1.38~2.13）、1.48（1.22~1.80）、1.41（1.16~1.70）。 结论： 性别、年龄、文化程度、家庭人均年收入、饮用水源、肉蛋奶类摄入与山东省农村地区40~69岁居民食管癌发生有关。.
Keywords: Esophageal neoplasms; Precancerous conditions; Risk factors; Screening.