In 2017, the American Society of Transplantation (AST) launched the Outstanding Questions in Transplantation Research forum to stimulate a community-wide discussion of how the field is evolving and to help identify areas where a better dialogue between clinicians and researchers could result in great advancements. Tolerance emerged as a topic of great interest to the AST community. This minireview provides an overview of clinical transplantation tolerance. Historical background followed by a review of the current status of attempts to establish tolerance in the clinic, highlighting the dynamic online discussion surrounding this important topic from the AST Transplantation Research forum, is provided.
Keywords: immunosuppression/immune modulation; stem cells; tolerance: chimerism; tolerance: clinical; tolerance: mechanisms; translational research/science.
© 2019 The American Society of Transplantation and the American Society of Transplant Surgeons.