The Respiratory Syncytial Virus Polymerase: A Multitasking Machine

Rachel Fearns

doi:10.1016/j.tim.2019.10.001

The Respiratory Syncytial Virus Polymerase: A Multitasking Machine

Trends Microbiol. 2019 Dec;27(12):969-971. doi: 10.1016/j.tim.2019.10.001. Epub 2019 Oct 28.

Author

Rachel Fearns¹

Affiliation

¹ Department of Microbiology, National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, 620 Albany Street, Boston, MA 02118, USA. Electronic address: rfearns@bu.edu.

PMID: 31672264
DOI: 10.1016/j.tim.2019.10.001

Abstract

Respiratory syncytial virus (RSV) inflicts a significant toll on human life. An essential element of the virus is its polymerase, a complex capable of transcribing and replicating the viral genome. In an exciting new advance, Gilman et al. resolve the structure of this polymerase, providing valuable mechanistic insight into its activities.

Keywords: capping; methyltransferase; mononegavirales; polymerase; respiratory syncytial virus; transcription.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Genome, Viral
Humans
Respiratory Syncytial Virus Infections*
Respiratory Syncytial Virus, Human / genetics*
Virus Replication

Abstract

Publication types

MeSH terms

Grants and funding